Brain mapping with Nexstim’s nTMS technology NBS® accurately defines the areas in the brain responsible for motor function—non-invasively. nTMS differs from fMRI by being a direct, causal method and there is wealth of clinical data showing good concordance of nTMS mapping with DES.1)
The NBS functional maps allow the radiotherapist to modify the dose plan in order to minimize undesired dosing of eloquent motor areas which need to be preserved. High doses of radiation are associated with cell death and high doses of radiation to motor areas are associated with a deterioration in patient’s motor function post-therapy.
Studies have shown that using nTMS to guide the orientation of the applied radiation beam allows for significantly reduced dosing to motor areas (-18.1%). Importantly, this reduction is achieved without compromising treatment of the tumors.2)
As a non-invasive method, NBS mapping is a valuable new tool for radiotherapists. NBS complements the use of non-surgical (non-invasive) treatment approaches. DICOM tools allow for direct export of NBS results into dose planning software for visualization.
1) Tarapore P, et al. Preoperative multimodal motor mapping: a comparison of magnetoencephalography imaging, navigated transcranial magnetic stimulation, and direct cortical stimulation. J Neurosurg. 2012 Aug; 117(2)
2)Schwendner, MJ. et al. The Role of Navigated Transcranial Magnetic Stimulation Motor Mapping in Adjuvant Radiotherapy Planning in Patients With Supratentorial Brain Metastases. Front Oncol. 2018 Oct 2;8:424.
The Nexstim Navigated Brain Stimulation (NBS) System 5 is indicated for non-invasive mapping of the primary motor cortex of the brain to its cortical gyrus. The Nexstim NBS System 5 provides information that may be used in the assessment of the primary motor cortex for pre-procedural planning.
Nexstim NexSpeech®, when used together with the NBS System 5, is indicated for non-invasive localization of cortical areas that do not contain essential speech function. NexSpeech® provides information that may be used in pre-surgical planning in patients undergoing brain surgery. Intra-operatively, the localization information provided by NexSpeech® is intended to be verified by direct cortical stimulation.
The Nexstim NBS System 5 and NBS System 5 with NexSpeech® are not intended to be used during a surgical procedure.
The Nexstim NBS System 5 and NBS System 5 with NexSpeech® are intended to be used by trained clinical professionals.