NexTalk-Europe newsletter highlights clinicians' backing for wider use of NBS in presurgical mapping

HELSINKI, Finland, July 7, 2014 – In this edition, we highlight the publication of a second large outcome study on NBS motor mapping performed by the Department of Neurosurgery, Charité University Hospital in Berlin. This new outcomes study increases the level of evidence for using NBS mapping in preoperative neurosurgical planning generated by a similar large study from Technische Universität München, Germany (TUM) published earlier this year.

In this large 365-patient study at Berlin, 250 patients mapped by NBS were matched with 115 patients operated on prior to NBS becoming available. The Charité clinicians found that the group of patients who had had resections based on NBS mapping data had more extensive tumor resections and patients with gliomas had significantly longer progression-free survival times. Importantly, one out of every four patients initially thought to have a tumor in the eloquent motor area actually did not - based on the NBS results - and 69% of these patients were able to benefit from surgery (the first-line treatment).

The two patient groups were well matched and all patients in both groups had brain tumor surgery guided by intraoperative direct cortical stimulation. The better outcomes in the NBS group patients were achieved with no increase in post-operative morbidity - there was a 28% lower incidence of post-operative deficits in the NBS group, although this difference did not reach statistical significance.

This year's 65th Annual Meeting of the German Society of Neurosurgery (DGNC) was an important breakthrough event for NBS. Navigated TMS (nTMS) was broadly discussed in a morning session on the Motor System and this year an entire session later in the week was dedicated specifically to nTMS in presurgical planning. In the nTMS session moderated by Dr. Thomas Picht and Dr. Sandro Krieg, remarkably 8 out of the 9 presentations were based on experiences with the Nexstim NBS System. In his presentation, Dr. Krieg noted that after adopting NBS mapping as standard preoperative procedure, length-of-stay (LOS) for neurosurgical patients was now 2 days shorter at the Technische Universität München.

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